Genetic characterization of dengue virus types 1 and 2 in India, with emphasis on the viruses circulating in Karnataka
نویسندگان
چکیده
Dengue, a viral disease transmitted by Aedes mosquitoes, is a serious global public health problem, infecting 50 to 100 million people each year in >100 countries and resulting in at least 20,000 deaths annually1,2. Dengue is caused by one of the four antigenically related dengue virus serotypes (DENV-1 to 4) belonging to the family Flaviviridae3. The viral genome is a single-stranded, positive-sense RNA of about 10.7 kb which encodes three structural and seven non-structural (NS) proteins in the order 5’-C-prM(M)E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5-3’4. Based on the nucleotide sequence of the envelope (E), E/NS1 or capsid-premembrane (CprM) gene, the four DENV serotypes have been classified phylogenetically into three to five genotypes with certain genotypes being further classified into lineages or clades5.
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